Ob/ob mouse livers show decreased oxidative phosphorylation efficiencies and anaerobic capacities after cold ischemia.

BACKGROUND: Hepatic steatosis is a major risk factor for graft failure in liver transplantation. Hepatic steatosis shows a greater negative influence on graft function following prolonged cold ischaemia. As the impact of steatosis on hepatocyte metabolism during extended cold ischaemia is not well-d...

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Bibliographic Details
Main Authors: Michael J J Chu, Anthony J R Hickey, Sherry Tagaloa, Linda Zhang, Anna J Dare, Julia R MacDonald, Mee-Ling Yeong, Adam S J R Bartlett, Anthony R J Phillips
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4067359?pdf=render