Murine liver repair via transient activation of regenerative pathways in hepatocytes using lipid nanoparticle-complexed nucleoside-modified mRNA

Murine liver repair via transient activation of regenerative pathways in hepatocytes using lipid nanoparticle-complexed nucleoside-modified mRNA

When severely or chronically injured, the liver loses ability to regenerate. Here, the authors utilize transient lipid nanoparticle-enclosed HGF and EGF-encoding mRNA delivery to induce hepatocyte proliferation and harness recovery of liver function in murine acute and chronic liver injury models.

Bibliographic Details
Main Authors: Fatima Rizvi, Elissa Everton, Anna R. Smith, Hua Liu, Elizabeth Osota, Mitchell Beattie, Ying Tam, Norbert Pardi, Drew Weissman, Valerie Gouon-Evans
Format: Article
Language:English
Published: Nature Publishing Group 2021-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-20903-3

Internet

https://doi.org/10.1038/s41467-021-20903-3

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