Murine liver repair via transient activation of regenerative pathways in hepatocytes using lipid nanoparticle-complexed nucleoside-modified mRNA
When severely or chronically injured, the liver loses ability to regenerate. Here, the authors utilize transient lipid nanoparticle-enclosed HGF and EGF-encoding mRNA delivery to induce hepatocyte proliferation and harness recovery of liver function in murine acute and chronic liver injury models.
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2021-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-20903-3 |
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doaj-92c5e809fade4febb8867b9abf7c2367 |
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doaj-92c5e809fade4febb8867b9abf7c23672021-01-31T12:19:49ZengNature Publishing GroupNature Communications2041-17232021-01-0112111010.1038/s41467-021-20903-3Murine liver repair via transient activation of regenerative pathways in hepatocytes using lipid nanoparticle-complexed nucleoside-modified mRNAFatima Rizvi0Elissa Everton1Anna R. Smith2Hua Liu3Elizabeth Osota4Mitchell Beattie5Ying Tam6Norbert Pardi7Drew Weissman8Valerie Gouon-Evans9Center for Regenerative Medicine and the Section of Gastroenterology of Boston University and Boston Medical CenterCenter for Regenerative Medicine and the Section of Gastroenterology of Boston University and Boston Medical CenterCenter for Regenerative Medicine and the Section of Gastroenterology of Boston University and Boston Medical CenterCenter for Regenerative Medicine and the Section of Gastroenterology of Boston University and Boston Medical CenterCenter for Regenerative Medicine and the Section of Gastroenterology of Boston University and Boston Medical CenterAcuitas TherapeuticsAcuitas TherapeuticsDepartment of Medicine, University of PennsylvaniaDepartment of Medicine, University of PennsylvaniaCenter for Regenerative Medicine and the Section of Gastroenterology of Boston University and Boston Medical CenterWhen severely or chronically injured, the liver loses ability to regenerate. Here, the authors utilize transient lipid nanoparticle-enclosed HGF and EGF-encoding mRNA delivery to induce hepatocyte proliferation and harness recovery of liver function in murine acute and chronic liver injury models.https://doi.org/10.1038/s41467-021-20903-3 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Fatima Rizvi Elissa Everton Anna R. Smith Hua Liu Elizabeth Osota Mitchell Beattie Ying Tam Norbert Pardi Drew Weissman Valerie Gouon-Evans |
| spellingShingle |
Fatima Rizvi Elissa Everton Anna R. Smith Hua Liu Elizabeth Osota Mitchell Beattie Ying Tam Norbert Pardi Drew Weissman Valerie Gouon-Evans Murine liver repair via transient activation of regenerative pathways in hepatocytes using lipid nanoparticle-complexed nucleoside-modified mRNA Nature Communications |
| author_facet |
Fatima Rizvi Elissa Everton Anna R. Smith Hua Liu Elizabeth Osota Mitchell Beattie Ying Tam Norbert Pardi Drew Weissman Valerie Gouon-Evans |
| author_sort |
Fatima Rizvi |
| title |
Murine liver repair via transient activation of regenerative pathways in hepatocytes using lipid nanoparticle-complexed nucleoside-modified mRNA |
| title_short |
Murine liver repair via transient activation of regenerative pathways in hepatocytes using lipid nanoparticle-complexed nucleoside-modified mRNA |
| title_full |
Murine liver repair via transient activation of regenerative pathways in hepatocytes using lipid nanoparticle-complexed nucleoside-modified mRNA |
| title_fullStr |
Murine liver repair via transient activation of regenerative pathways in hepatocytes using lipid nanoparticle-complexed nucleoside-modified mRNA |
| title_full_unstemmed |
Murine liver repair via transient activation of regenerative pathways in hepatocytes using lipid nanoparticle-complexed nucleoside-modified mRNA |
| title_sort |
murine liver repair via transient activation of regenerative pathways in hepatocytes using lipid nanoparticle-complexed nucleoside-modified mrna |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2021-01-01 |
| description |
When severely or chronically injured, the liver loses ability to regenerate. Here, the authors utilize transient lipid nanoparticle-enclosed HGF and EGF-encoding mRNA delivery to induce hepatocyte proliferation and harness recovery of liver function in murine acute and chronic liver injury models. |
| url |
https://doi.org/10.1038/s41467-021-20903-3 |
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