Intestinal de novo phosphatidylcholine synthesis is required for dietary lipid absorption and metabolic homeostasis

Intestinal de novo phosphatidylcholine synthesis is required for dietary lipid absorption and metabolic homeostasis

De novo phosphatidylcholine (PC) synthesis via CTP:phosphocholine cytidylyltransferase-α (CTα) is required for VLDL secretion. To determine the precise role of de novo PC synthesis in intestinal lipid metabolism, we deleted CTα exclusively in the intestinal epithelium of mice (CTαIKO mice). When fed...

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Bibliographic Details
Main Authors: John P. Kennelly, Jelske N. van der Veen, Randal C. Nelson, Kelly-Ann Leonard, Rick Havinga, Jean Buteau, Folkert Kuipers, René L. Jacobs
Format: Article
Language:English
Published: Elsevier 2018-09-01
Series:Journal of Lipid Research
Subjects:
bile
phospholipids
lipids and lipoprotein metabolism
chylomicrons
triglycerides
intestine
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520335380

Internet

http://www.sciencedirect.com/science/article/pii/S0022227520335380

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