cAMP triggers Na+ absorption by distal airway surface epithelium in cystic fibrosis swine

cAMP triggers Na+ absorption by distal airway surface epithelium in cystic fibrosis swine

Summary: A controversial hypothesis pertaining to cystic fibrosis (CF) lung disease is that the CF transmembrane conductance regulator (CFTR) channel fails to inhibit the epithelial Na+ channel (ENaC), yielding increased Na+ reabsorption and airway dehydration. We use a non-invasive self-referencing...

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Bibliographic Details
Main Authors: Xiaojie Luan, Yen Le, Santosh Jagadeeshan, Brendan Murray, James L. Carmalt, Tanya Duke, Shannon Beazley, Masako Fujiyama, Kurtis Swekla, Bridget Gray, Monique Burmester, Veronica A. Campanucci, Alan Shipley, Terry E. Machen, Julian S. Tam, Juan P. Ianowski
Format: Article
Language:English
Published: Elsevier 2021-10-01
Series:Cell Reports
Subjects:
ENaC
CFTR
cystic fibrosis
CF
airway dehydration
distal airways
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721012559

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http://www.sciencedirect.com/science/article/pii/S2211124721012559

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