STAT Signaling Modifies Ascl1 Chromatin Binding and Limits Neural Regeneration from Muller Glia in Adult Mouse Retina

Summary: Müller glia (MG) serve as sources for retinal regeneration in non-mammalian vertebrates. We find that this process can be induced in mouse MG, after injury, by transgenic expression of the proneural transcription factor Ascl1 and the HDAC inhibitor TSA. However, new neurons are generated on...

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Bibliographic Details
Main Authors: Nikolas L. Jorstad, Matthew S. Wilken, Levi Todd, Connor Finkbeiner, Paul Nakamura, Nicholas Radulovich, Marcus J. Hooper, Alex Chitsazan, Brent A. Wilkerson, Fred Rieke, Thomas A. Reh
Format: Article
Language:English
Published: Elsevier 2020-02-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720301005