Zinc coordination is required for and regulates transcription activation by Epstein-Barr nuclear antigen 1.
Epstein-Barr Nuclear Antigen 1 (EBNA1) is essential for Epstein-Barr virus to immortalize naïve B-cells. Upon binding a cluster of 20 cognate binding-sites termed the family of repeats, EBNA1 transactivates promoters for EBV genes that are required for immortalization. A small domain, termed UR1, th...
Main Authors: | , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2009-06-01
|
Series: | PLoS Pathogens |
Online Access: | http://europepmc.org/articles/PMC2690687?pdf=render |