Zinc coordination is required for and regulates transcription activation by Epstein-Barr nuclear antigen 1.

Zinc coordination is required for and regulates transcription activation by Epstein-Barr nuclear antigen 1.

Epstein-Barr Nuclear Antigen 1 (EBNA1) is essential for Epstein-Barr virus to immortalize naïve B-cells. Upon binding a cluster of 20 cognate binding-sites termed the family of repeats, EBNA1 transactivates promoters for EBV genes that are required for immortalization. A small domain, termed UR1, th...

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Bibliographic Details
Main Authors: Siddhesh Aras, Gyanendra Singh, Kenneth Johnston, Timothy Foster, Ashok Aiyar
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-06-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC2690687?pdf=render

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