Pioglitazone improves cognitive function via increasing insulin sensitivity and strengthening antioxidant defense system in fructose-drinking insulin resistance rats.

Pioglitazone improves cognitive function via increasing insulin sensitivity and strengthening antioxidant defense system in fructose-drinking insulin resistance rats.

Insulin resistance (IR) links Alzheimer's disease (AD) with oxidative damage, cholinergic deficit, and cognitive impairment. Peroxisome proliferator-activated receptor γ (PPARγ) agonist pioglitazone previously used to treat type 2 diabetes mellitus (T2DM) has also been demonstrated to be effect...

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Bibliographic Details
Main Authors: Qing-Qing Yin, Jin-Jing Pei, Song Xu, Ding-Zhen Luo, Si-Qing Dong, Meng-Han Sun, Li You, Zhi-Jian Sun, Xue-Ping Liu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3603906?pdf=render

Internet

http://europepmc.org/articles/PMC3603906?pdf=render

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