Pioglitazone improves cognitive function via increasing insulin sensitivity and strengthening antioxidant defense system in fructose-drinking insulin resistance rats.
Insulin resistance (IR) links Alzheimer's disease (AD) with oxidative damage, cholinergic deficit, and cognitive impairment. Peroxisome proliferator-activated receptor γ (PPARγ) agonist pioglitazone previously used to treat type 2 diabetes mellitus (T2DM) has also been demonstrated to be effect...
Main Authors: | , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2013-01-01
|
Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3603906?pdf=render |
id |
doaj-92dea604fa1e46589f4cbf16732157f4 |
---|---|
record_format |
Article |
spelling |
doaj-92dea604fa1e46589f4cbf16732157f42020-11-25T01:19:08ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0183e5931310.1371/journal.pone.0059313Pioglitazone improves cognitive function via increasing insulin sensitivity and strengthening antioxidant defense system in fructose-drinking insulin resistance rats.Qing-Qing YinJin-Jing PeiSong XuDing-Zhen LuoSi-Qing DongMeng-Han SunLi YouZhi-Jian SunXue-Ping LiuInsulin resistance (IR) links Alzheimer's disease (AD) with oxidative damage, cholinergic deficit, and cognitive impairment. Peroxisome proliferator-activated receptor γ (PPARγ) agonist pioglitazone previously used to treat type 2 diabetes mellitus (T2DM) has also been demonstrated to be effective in anti-inflammatory reaction and anti-oxidative stress in the animal models of AD and other neuroinflammatory diseases. Here, we investigated the effect of pioglitazone on learning and memory impairment and the molecular events that may cause it in fructose-drinking insulin resistance rats. We found that long-term fructose-drinking causes insulin resistance, oxidative stress, down-regulated activity of cholinergic system, and cognitive deficit, which could be ameliorated by pioglitazone administration. The results from the present study provide experimental evidence for using pioglitazone in the treatment of brain damage caused by insulin resistance.http://europepmc.org/articles/PMC3603906?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Qing-Qing Yin Jin-Jing Pei Song Xu Ding-Zhen Luo Si-Qing Dong Meng-Han Sun Li You Zhi-Jian Sun Xue-Ping Liu |
spellingShingle |
Qing-Qing Yin Jin-Jing Pei Song Xu Ding-Zhen Luo Si-Qing Dong Meng-Han Sun Li You Zhi-Jian Sun Xue-Ping Liu Pioglitazone improves cognitive function via increasing insulin sensitivity and strengthening antioxidant defense system in fructose-drinking insulin resistance rats. PLoS ONE |
author_facet |
Qing-Qing Yin Jin-Jing Pei Song Xu Ding-Zhen Luo Si-Qing Dong Meng-Han Sun Li You Zhi-Jian Sun Xue-Ping Liu |
author_sort |
Qing-Qing Yin |
title |
Pioglitazone improves cognitive function via increasing insulin sensitivity and strengthening antioxidant defense system in fructose-drinking insulin resistance rats. |
title_short |
Pioglitazone improves cognitive function via increasing insulin sensitivity and strengthening antioxidant defense system in fructose-drinking insulin resistance rats. |
title_full |
Pioglitazone improves cognitive function via increasing insulin sensitivity and strengthening antioxidant defense system in fructose-drinking insulin resistance rats. |
title_fullStr |
Pioglitazone improves cognitive function via increasing insulin sensitivity and strengthening antioxidant defense system in fructose-drinking insulin resistance rats. |
title_full_unstemmed |
Pioglitazone improves cognitive function via increasing insulin sensitivity and strengthening antioxidant defense system in fructose-drinking insulin resistance rats. |
title_sort |
pioglitazone improves cognitive function via increasing insulin sensitivity and strengthening antioxidant defense system in fructose-drinking insulin resistance rats. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2013-01-01 |
description |
Insulin resistance (IR) links Alzheimer's disease (AD) with oxidative damage, cholinergic deficit, and cognitive impairment. Peroxisome proliferator-activated receptor γ (PPARγ) agonist pioglitazone previously used to treat type 2 diabetes mellitus (T2DM) has also been demonstrated to be effective in anti-inflammatory reaction and anti-oxidative stress in the animal models of AD and other neuroinflammatory diseases. Here, we investigated the effect of pioglitazone on learning and memory impairment and the molecular events that may cause it in fructose-drinking insulin resistance rats. We found that long-term fructose-drinking causes insulin resistance, oxidative stress, down-regulated activity of cholinergic system, and cognitive deficit, which could be ameliorated by pioglitazone administration. The results from the present study provide experimental evidence for using pioglitazone in the treatment of brain damage caused by insulin resistance. |
url |
http://europepmc.org/articles/PMC3603906?pdf=render |
work_keys_str_mv |
AT qingqingyin pioglitazoneimprovescognitivefunctionviaincreasinginsulinsensitivityandstrengtheningantioxidantdefensesysteminfructosedrinkinginsulinresistancerats AT jinjingpei pioglitazoneimprovescognitivefunctionviaincreasinginsulinsensitivityandstrengtheningantioxidantdefensesysteminfructosedrinkinginsulinresistancerats AT songxu pioglitazoneimprovescognitivefunctionviaincreasinginsulinsensitivityandstrengtheningantioxidantdefensesysteminfructosedrinkinginsulinresistancerats AT dingzhenluo pioglitazoneimprovescognitivefunctionviaincreasinginsulinsensitivityandstrengtheningantioxidantdefensesysteminfructosedrinkinginsulinresistancerats AT siqingdong pioglitazoneimprovescognitivefunctionviaincreasinginsulinsensitivityandstrengtheningantioxidantdefensesysteminfructosedrinkinginsulinresistancerats AT menghansun pioglitazoneimprovescognitivefunctionviaincreasinginsulinsensitivityandstrengtheningantioxidantdefensesysteminfructosedrinkinginsulinresistancerats AT liyou pioglitazoneimprovescognitivefunctionviaincreasinginsulinsensitivityandstrengtheningantioxidantdefensesysteminfructosedrinkinginsulinresistancerats AT zhijiansun pioglitazoneimprovescognitivefunctionviaincreasinginsulinsensitivityandstrengtheningantioxidantdefensesysteminfructosedrinkinginsulinresistancerats AT xuepingliu pioglitazoneimprovescognitivefunctionviaincreasinginsulinsensitivityandstrengtheningantioxidantdefensesysteminfructosedrinkinginsulinresistancerats |
_version_ |
1725139865690963968 |