Lysosome dysfunction as a cause of neurodegenerative diseases: Lessons from frontotemporal dementia and amyotrophic lateral sclerosis

Lysosome dysfunction as a cause of neurodegenerative diseases: Lessons from frontotemporal dementia and amyotrophic lateral sclerosis

Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) are fatal neurodegenerative disorders that are thought to exist on a clinical and pathological spectrum. FTD and ALS are linked by shared genetic causes (e.g. C9orf72 hexanucleotide repeat expansions) and neuropathology, such as i...

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Bibliographic Details
Main Authors: Jessica Root, Paola Merino, Austin Nuckols, Michelle Johnson, Thomas Kukar
Format: Article
Language:English
Published: Elsevier 2021-07-01
Series:Neurobiology of Disease
Subjects:
Amyotrophic lateral sclerosis (ALS)
Frontotemporal dementia (FTD)
Frontotemporal lobar degeneration (FTLD)
Alzheimer's disease and related dementias (ADRD)
Lysosome dysfunction
Autophagy
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996121001091

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http://www.sciencedirect.com/science/article/pii/S0969996121001091

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