A mouse model of autism implicates endosome pH in the regulation of presynaptic calcium entry

A mouse model of autism implicates endosome pH in the regulation of presynaptic calcium entry

The Na+/H+ exchanger NHE9 is proposed to regulate the H+ electrochemical gradient across endosomal membranes. Here, the authors find that NHE9 knockout mice show autism spectrum disorder-like behaviors and disrupted synaptic vesicle exocytosis due to impaired presynaptic calcium entry.

Bibliographic Details
Main Authors: Julie C. Ullman, Jing Yang, Michael Sullivan, Jacob Bendor, Jonathan Levy, Ellen Pham, Katlin Silm, Helia Seifikar, Vikaas S. Sohal, Roger A. Nicoll, Robert H. Edwards
Format: Article
Language:English
Published: Nature Publishing Group 2018-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-02716-5

Internet

https://doi.org/10.1038/s41467-017-02716-5

Similar Items