In Vitro Pharmacological Profile of a New Small Molecule Bradykinin B2 Receptor Antagonist

In Vitro Pharmacological Profile of a New Small Molecule Bradykinin B2 Receptor Antagonist

We here report the discovery and early characterization of Compound 3, a representative of a novel class of small molecule bradykinin (BK) B2 receptor antagonists, and its superior profile to the prior art B2 receptor antagonists Compound 1 and Compound 2. Compound 3, Compound 2, and Compound 1 are...

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Bibliographic Details
Main Authors: Anne Lesage, Christoph Gibson, François Marceau, Horst-Dieter Ambrosi, Jörn Saupe, Werner Katzer, Brigitte Loenders, Xavier Charest-Morin, Jochen Knolle
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Pharmacology
Subjects:
bradykinin
B2 receptor
small molecule antagonists
icatibant
human umbilical vein
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00916/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.00916/full

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