Screening of Novel Pharmacogenetic Candidates for Mercaptopurine-Induced Toxicity in Patients With Acute Lymphoblastic Leukemia

Screening of Novel Pharmacogenetic Candidates for Mercaptopurine-Induced Toxicity in Patients With Acute Lymphoblastic Leukemia

A small proportion of patients with acute lymphoblastic leukemia (ALL) may experience severe leukopenia after treating with 6-mercaptopurine (6MP), which can be largely explained by germline variants in TPMT and NUDT15. However, a minority of patients who suffered such adverse drug reaction have NUD...

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Bibliographic Details
Main Authors: Minyuan Cao, Dandan Yin, Yun Qin, Fei Liao, Yali Su, Xuyang Xia, Ju Gao, Yiping Zhu, Wei Zhang, Yang Shu, Xiaoxi Lu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Pharmacology
Subjects:
mercaptopurine
leukopenia
hepatoxicity
adverse drug reaction
pharmacogenetics
CYP2A7
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00267/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.00267/full

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