Accelerating Gene Discovery by Phenotyping Whole-Genome Sequenced Multi-mutation Strains and Using the Sequence Kernel Association Test (SKAT).

Accelerating Gene Discovery by Phenotyping Whole-Genome Sequenced Multi-mutation Strains and Using the Sequence Kernel Association Test (SKAT).

Forward genetic screens represent powerful, unbiased approaches to uncover novel components in any biological process. Such screens suffer from a major bottleneck, however, namely the cloning of corresponding genes causing the phenotypic variation. Reverse genetic screens have been employed as a way...

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Bibliographic Details
Main Authors: Tiffany A Timbers, Stephanie J Garland, Swetha Mohan, Stephane Flibotte, Mark Edgley, Quintin Muncaster, Vinci Au, Erica Li-Leger, Federico I Rosell, Jerry Cai, Suzanne Rademakers, Gert Jansen, Donald G Moerman, Michel R Leroux
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-08-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC4980031?pdf=render

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http://europepmc.org/articles/PMC4980031?pdf=render

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