Topological DNA damage, telomere attrition and T cell senescence during chronic viral infections

Topological DNA damage, telomere attrition and T cell senescence during chronic viral infections

Abstract Background T cells play a key role in controlling viral infections; however, the underlying mechanisms regulating their functions during human viral infections remain incompletely understood. Here, we used CD4 T cells derived from individuals with chronic viral infections or healthy T cells...

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Bibliographic Details
Main Authors: Yingjie Ji, Xindi Dang, Lam Ngoc Thao Nguyen, Lam Nhat Nguyen, Juan Zhao, Dechao Cao, Sushant Khanal, Madison Schank, Xiao Y. Wu, Zheng D. Morrison, Yue Zou, Mohamed El Gazzar, Shunbin Ning, Ling Wang, Jonathan P. Moorman, Zhi Q. Yao
Format: Article
Language:English
Published: BMC 2019-06-01
Series:Immunity & Ageing
Subjects:
HBV
HCV
HIV
Topological DNA damage
Telomere attrition
T cell senescence
Online Access:http://link.springer.com/article/10.1186/s12979-019-0153-z

Internet

http://link.springer.com/article/10.1186/s12979-019-0153-z

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