A Single L/D-Substitution at Q4 of the mInsA2-10 Epitope Prevents Type 1 Diabetes in Humanized NOD Mice

A Single L/D-Substitution at Q4 of the mInsA2-10 Epitope Prevents Type 1 Diabetes in Humanized NOD Mice

Autoreactive CD8+ T cells play an indispensable key role in the destruction of pancreatic islet β-cells and the initiation of type 1 diabetes (T1D). Insulin is an essential β-cell autoantigen in T1D. An HLA-A*0201-restricted epitope of insulin A chain (mInsA2-10) is an immunodominant ligand for auto...

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Bibliographic Details
Main Authors: Mengjun Zhang, Yuanqiang Wang, Xiangqian Li, Gang Meng, Xiaoling Chen, Lina Wang, Zhihua Lin, Li Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Immunology
Subjects:
type 1 diabetes
altered peptide ligand
D-amino acid substitution
mInsA2-10
NOD.β2mnull.HHD mice
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.713276/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.713276/full

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