Recombinant TSG-6 protein inhibits the growth of capsule fibroblasts in frozen shoulder via suppressing the TGF-β/Smad2 signal pathway

Recombinant TSG-6 protein inhibits the growth of capsule fibroblasts in frozen shoulder via suppressing the TGF-β/Smad2 signal pathway

Abstract Background The tumor necrosis factor-stimulated gene-6 (TSG-6) has been confirmed to inhibit inflammation. It is now generally accepted that local inflammatory stimulation around shoulder capsule causes proliferative fibrosis. This study aims to investigate the mechanism of recombinant TSG-...

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Bibliographic Details
Main Authors: Zhongfan Liu, Yongrong Pei, Hao Zeng, Yibo Yang, Meng Que, Yuhui Xiao, Jing Wang, Xiaojun Weng
Format: Article
Language:English
Published: BMC 2021-09-01
Series:Journal of Orthopaedic Surgery and Research
Subjects:
Recombinant TSG-6 protein
TGF-β/Smad2 signaling pathway
Frozen shoulder capsule fibroblasts
Cell proliferation
Apoptosis
Inflammatory response
Online Access:https://doi.org/10.1186/s13018-021-02705-x

Internet

https://doi.org/10.1186/s13018-021-02705-x

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