The Effect of Trichostatin-A and Tumour Necrosis Factor on Expression of Splice Variants of the MaxiK and L-Type Channels in Human Myometrium

The Effect of Trichostatin-A and Tumour Necrosis Factor on Expression of Splice Variants of the MaxiK and L-Type Channels in Human Myometrium

The onset of human parturition is associated with up-regulation of pro-inflammatory cytokines including TNF as well as changes in ion flux, principally Ca2+ and K+, across the myometrial myocytes membrane. Elevation of intra-cellular Ca2+ from the sarcoplasmic reticulum opens L-type Ca2+ channels; i...

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Bibliographic Details
Main Authors: Sarah L. Waite, Saurabh V. Gandhi, Raheela N. Khan, Neil R. Chapman
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-07-01
Series:Frontiers in Physiology
Subjects:
Parturition
TNF
splice variants
TSA
LTCC
MaxiK
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2014.00261/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphys.2014.00261/full

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