Expression of the Extracellular Sulfatase SULF2 Affects Survival of Head and Neck Squamous Cell Carcinoma Patients

Expression of the Extracellular Sulfatase SULF2 Affects Survival of Head and Neck Squamous Cell Carcinoma Patients

Sulfation of heparan sulfate proteoglycans (HSPG) regulates signaling of growth factor receptors via specific interactions with the sulfate groups. 6-O-Sulfation of HSPG is an impactful modification regulated by the activities of dedicated extracellular endosulfatases. Specifically, extracellular su...

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Bibliographic Details
Main Authors: Yang Yang, Jaeil Ahn, Rekha Raghunathan, Bhaskar V. Kallakury, Bruce Davidson, Zuzana Brnakova Kennedy, Joseph Zaia, Radoslav Goldman
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Oncology
Subjects:
head and neck squamous cell carcinoma
extracellular sulfatase Sulf-2
SULF2
heparan sulfate,
6-O-sulfation
patient survival
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2020.582827/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2020.582827/full

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