Transition between acute and chronic hepatotoxicity in mice is associated with impaired energy metabolism and induction of mitochondrial heme oxygenase-1.

Transition between acute and chronic hepatotoxicity in mice is associated with impaired energy metabolism and induction of mitochondrial heme oxygenase-1.

The formation of protein inclusions is frequently associated with chronic metabolic diseases. In mice, short-term intoxication with 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC) leads to hepatocellular damage indicated by elevated serum liver enzyme activities, whereas only minor morphological cha...

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Bibliographic Details
Main Authors: Aniket Nikam, Jay V Patankar, Carolin Lackner, Elisabeth Schöck, Dagmar Kratky, Kurt Zatloukal, Peter M Abuja
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3675145?pdf=render

Internet

http://europepmc.org/articles/PMC3675145?pdf=render

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