A germline polymorphism of thymine DNA glycosylase induces genomic instability and cellular transformation.

A germline polymorphism of thymine DNA glycosylase induces genomic instability and cellular transformation.

Thymine DNA glycosylase (TDG) functions in base excision repair, a DNA repair pathway that acts in a lesion-specific manner to correct individual damaged or altered bases. TDG preferentially catalyzes the removal of thymine and uracil paired with guanine, and is also active on 5-fluorouracil (5-FU)...

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Bibliographic Details
Main Authors: Ashley Sjolund, Antonia A Nemec, Nicolas Paquet, Aishwarya Prakash, Patrick Sung, Sylvie Doublié, Joann B Sweasy
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-11-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC4222680?pdf=render

Internet

http://europepmc.org/articles/PMC4222680?pdf=render

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