Effect of diabetes status and hyperglycemia on global DNA methylation and hydroxymethylation

Effect of diabetes status and hyperglycemia on global DNA methylation and hydroxymethylation

Type 2 diabetes mellitus (T2DM) is characterized by oxidative stress that could lead to chronic micro- and macrovascular complications. We hypothesized that some of the target organ damage is mediated by oxidative alterations in epigenetic mechanisms involving DNA methylation (5mC) and DNA hydroxyme...

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Bibliographic Details
Main Authors: Angelina Perna-Chaux, Nicolás Steven Rojas-Villamizar, Angélica Díaz-Basabe, Diana Carolina Polanía-Villanueva, María Fernanda Jácome, Carlos Olimpo Mendivil, Helena Groot, Valeriano López-Segura
Format: Article
Language:English
Published: Bioscientifica 2017-11-01
Series:Endocrine Connections
Subjects:
DNA methylation
DNA hydroxymethylation
diabetes
oxidation
Online Access:http://www.endocrineconnections.com/content/6/8/708.full

Internet

http://www.endocrineconnections.com/content/6/8/708.full

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