A Combined In Vivo HSC Transduction/Selection Approach Results in Efficient and Stable Gene Expression in Peripheral Blood Cells in Mice

We recently reported on an in vivo hematopoietic stem cell (HSC) gene therapy approach. It involves the subcutaneous injections of G-CSF/AMD3100 to mobilize HSCs from the bone marrow into the peripheral blood stream and the intravenous injection of an integrating helper-dependent adenovirus vector s...

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Bibliographic Details
Main Authors:	Hongjie Wang, Maximilian Richter, Nikoletta Psatha, Chang Li, Jiho Kim, Jing Liu, Anja Ehrhardt, Susan K. Nilsson, Benjamin Cao, Donna Palmer, Philip Ng, Zsuzsanna Izsvák, Kevin G. Haworth, Hans-Peter Kiem, Thalia Papayannopoulou, André Lieber
Format:	Article
Language:	English
Published:	Elsevier 2018-03-01
Series:	Molecular Therapy: Methods & Clinical Development
Subjects:	hematopoietic stem cells adenovirus mobilization
Online Access:	http://www.sciencedirect.com/science/article/pii/S2329050117301201

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http://www.sciencedirect.com/science/article/pii/S2329050117301201

A Combined In Vivo HSC Transduction/Selection Approach Results in Efficient and Stable Gene Expression in Peripheral Blood Cells in Mice

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