Chemical Modification of Influenza CD8+ T-Cell Epitopes Enhances Their Immunogenicity Regardless of Immunodominance.

Chemical Modification of Influenza CD8+ T-Cell Epitopes Enhances Their Immunogenicity Regardless of Immunodominance.

T cells are essential players in the defense against infection. By targeting the MHC class I antigen-presenting pathway with peptide-based vaccines, antigen-specific T cells can be induced. However, low immunogenicity of peptides poses a challenge. Here, we set out to increase immunogenicity of infl...

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Bibliographic Details
Main Authors: Sietske K Rosendahl Huber, Jolien J Luimstra, Josine van Beek, Rieuwert Hoppes, Ronald H J Jacobi, Marion Hendriks, Kim Kapteijn, Casper Ouwerkerk, Boris Rodenko, Huib Ovaa, Jørgen de Jonge
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4917206?pdf=render

Internet

http://europepmc.org/articles/PMC4917206?pdf=render

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