OTS167 blocks FLT3 translation and synergizes with FLT3 inhibitors in FLT3 mutant acute myeloid leukemia

OTS167 blocks FLT3 translation and synergizes with FLT3 inhibitors in FLT3 mutant acute myeloid leukemia

Abstract Internal tandem duplication (-ITD) mutations of Fms-like tyrosine kinase 3 (FLT3) provide growth and pro-survival signals in the context of established driver mutations in FLT3 mutant acute myeloid leukemia (AML). Maternal embryonic leucine zipper kinase (MELK) is an aberrantly expressed ge...

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Bibliographic Details
Main Authors: Bartholomew J. Eisfelder, Caner Saygin, Joseph Wynne, Margaret W. Colton, Mariafausta Fischietti, Elspeth M. Beauchamp, Jason X. Cheng, Olatoyosi Odenike, Gail Roboz, Houda Alachkar, Wendy Stock
Format: Article
Language:English
Published: Nature Publishing Group 2021-03-01
Series:Blood Cancer Journal
Online Access:https://doi.org/10.1038/s41408-021-00433-3

Internet

https://doi.org/10.1038/s41408-021-00433-3

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