The compartmentalisation of phosphorylated free oligosaccharides in cells from a CDG Ig patient reveals a novel ER-to-cytosol translocation process.

The compartmentalisation of phosphorylated free oligosaccharides in cells from a CDG Ig patient reveals a novel ER-to-cytosol translocation process.

BACKGROUND: Biosynthesis of the dolichol linked oligosaccharide (DLO) required for protein N-glycosylation starts on the cytoplasmic face of the ER to give Man(5)GlcNAc(2)-PP-dolichol, which then flips into the ER for further glycosylation yielding mature DLO (Glc(3)Man(9)GlcNAc(2)-PP-dolichol). Aft...

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Bibliographic Details
Main Authors: Delphine Peric, Christelle Durrant-Arico, Christophe Delenda, Thierry Dupré, Pascale De Lonlay, Hélène Ogier de Baulny, Cécile Pelatan, Brigitte Bader-Meunier, Olivier Danos, Isabelle Chantret, Stuart E H Moore
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2907391?pdf=render

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http://europepmc.org/articles/PMC2907391?pdf=render

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