Evidence of evolutionary constraints that influences the sequence composition and diversity of mitochondrial matrix targeting signals.

Mitochondrial targeting signals (MTSs) are responsible for trafficking nuclear encoded proteins to their final destination within mitochondria. These sequences are diverse, sharing little amino acid homology and vary significantly in length, and although the formation of a positively-charged amphiph...

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Bibliographic Details
Main Authors: Stephen R Doyle, Naga R P Kasinadhuni, Chee Kai Chan, Warwick N Grant
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3692466?pdf=render