Optimized Conjugation of Fluvastatin to HIV-1 TAT Displays Enhanced Pro-Apoptotic Activity in HepG2 Cells

Optimized Conjugation of Fluvastatin to HIV-1 TAT Displays Enhanced Pro-Apoptotic Activity in HepG2 Cells

Accumulating evidence indicates that statins reduce the risk of different cancers and inhibit the proliferation of liver cancer cells. This study aims to explore whether the electrostatic conjugation of optimized fluvastatin (FLV) to human immunodeficiency virus type 1 (HIV-1) trans-activator transc...

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Bibliographic Details
Main Authors: Lamya H. Al-Wahaibi, Muneera S. M. Al-Saleem, Osama A. A. Ahmed, Usama A. Fahmy, Nabil A. Alhakamy, Basma G. Eid, Ashraf B. Abdel-Naim, Wael M. Abdel-Mageed, Maha M. AlRasheed, Gamal A. Shazly
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:International Journal of Molecular Sciences
Subjects:
fluvastatin
HIV-TAT
HepG2 cells
apoptosis
cationic peptide
cancer
Online Access:https://www.mdpi.com/1422-0067/21/11/4138

Internet

https://www.mdpi.com/1422-0067/21/11/4138

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