Proline-Rich Motifs Control G2-CDK Target Phosphorylation and Priming an Anchoring Protein for Polo Kinase Localization

Proline-Rich Motifs Control G2-CDK Target Phosphorylation and Priming an Anchoring Protein for Polo Kinase Localization

Summary: The hydrophobic patch (hp), a docking pocket on cyclins of CDKs (cyclin-dependent kinases), has been thought to accommodate a single short linear motif (SLiM), the “RxL or Cy” docking motif. Here we show that hp can bind different motifs with high specificity. We identify a PxxPxF motif tha...

Full description

Bibliographic Details
Main Authors: Mihkel Örd, Kait Kaarel Puss, Rait Kivi, Kaidi Möll, Tuuliki Ojala, Irina Borovko, Ilona Faustova, Rainis Venta, Ervin Valk, Mardo Kõivomägi, Mart Loog
Format: Article
Language:English
Published: Elsevier 2020-06-01
Series:Cell Reports
Subjects:
cell cycle
cyclin-dependent kinase
Polo kinase
kinase specificity
short linear motif
SLiM
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720307373

Internet

http://www.sciencedirect.com/science/article/pii/S2211124720307373

Similar Items