Role of the GH-IGF1 axis on the hypothalamus–pituitary–testicular axis function: lessons from Laron syndrome

Role of the GH-IGF1 axis on the hypothalamus–pituitary–testicular axis function: lessons from Laron syndrome

Background: Animal studies suggest that insulin-like growth factor 1 (IGF1 ) may influence the function of the hypothalamus–pituitary–testicular axis, especially in childhood, but the evidence in humans is scanty. Laron syndrome, a human model of IGF1 deficiency, may help to solve this issue. Purp...

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Bibliographic Details
Main Authors: Rossella Cannarella, Andrea Crafa, Sandro La Vignera, Rosita A Condorelli, Aldo E Calogero
Format: Article
Language:English
Published: Bioscientifica 2021-09-01
Series:Endocrine Connections
Subjects:
laron syndrome
igf1
oligozoospermia
puberty
testicular volume
micropenis
Online Access:https://ec.bioscientifica.com/view/journals/ec/10/9/EC-21-0252.xml

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https://ec.bioscientifica.com/view/journals/ec/10/9/EC-21-0252.xml

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