Brain region–specific lipid alterations in the PLB4 hBACE1 knock-in mouse model of Alzheimer’s disease

Brain region–specific lipid alterations in the PLB4 hBACE1 knock-in mouse model of Alzheimer’s disease

Abstract Background Lipid dysregulation is associated with several key characteristics of Alzheimer’s disease (AD), including amyloid-β and tau neuropathology, neurodegeneration, glucose hypometabolism, as well as synaptic and mitochondrial dysfunction. The β-site amyloid precursor protein cleavage...

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Bibliographic Details
Main Authors: Madhurima Dey, Frank J. Gunn-Moore, Bettina Platt, Terry K. Smith
Format: Article
Language:English
Published: BMC 2020-08-01
Series:Lipids in Health and Disease
Subjects:
PLB4
Quantitative lipidomics
Brain regions
Online Access:http://link.springer.com/article/10.1186/s12944-020-01367-8

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http://link.springer.com/article/10.1186/s12944-020-01367-8

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