PDE2A Is Indispensable for Mouse Liver Development and Hematopoiesis

PDE2A Is Indispensable for Mouse Liver Development and Hematopoiesis

Phosphodiesterase 2A (PDE2A) is a cAMP-cGMP hydrolyzing enzyme essential for mouse development and the <i>PDE2A</i> knockout model (<i>PDE2A</i><sup>−/−</sup>) is embryonic lethal. Notably, livers of <i>PDE2A</i><sup>−/−</sup> embryos at em...

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Bibliographic Details
Main Authors: Federica Barbagallo, Valentina Rotilio, Maria Rita Assenza, Salvatore Aguanno, Tiziana Orsini, Sabrina Putti, Andrea M. Isidori, Andrea Lenzi, Fabio Naro, Luciana De Angelis, Manuela Pellegrini
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:International Journal of Molecular Sciences
Subjects:
phosphodiesterase 2A
fetal liver
cAMP
ICER
apoptosis
hematopoiesis
Online Access:https://www.mdpi.com/1422-0067/21/8/2902

Internet

https://www.mdpi.com/1422-0067/21/8/2902

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