Using CRISPR to enhance T cell effector function for therapeutic applications
T cells are critical to fight pathogenic microbes and combat malignantly transformed cells in the fight against cancer. To exert their effector function, T cells produce effector molecules, such as the pro-inflammatory cytokines IFN-γ, TNF-α and IL-2. Tumors possess many inhibitory mechanisms that d...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2021-03-01
|
| Series: | Cytokine: X |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S259015322030029X |