Level of neo-epitope predecessor and mutation type determine T cell activation of MHC binding peptides

Level of neo-epitope predecessor and mutation type determine T cell activation of MHC binding peptides

Abstract Background Targeting epitopes derived from neo-antigens (or “neo-epitopes”) represents a promising immunotherapy approach with limited off-target effects. However, most peptides predicted using MHC binding prediction algorithms do not induce a CD8 + T cell response, and there is a crucial n...

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Bibliographic Details
Main Authors: Hanan Besser, Sharon Yunger, Efrat Merhavi-Shoham, Cyrille J. Cohen, Yoram Louzoun
Format: Article
Language:English
Published: BMJ Publishing Group 2019-05-01
Series:Journal for ImmunoTherapy of Cancer
Subjects:
T cell activation
Machine Learning
Neoantigen
MHC-binding peptides
Online Access:http://link.springer.com/article/10.1186/s40425-019-0595-z

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http://link.springer.com/article/10.1186/s40425-019-0595-z

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