Irisin directly stimulates osteoclastogenesis and bone resorption in vitro and in vivo

Irisin directly stimulates osteoclastogenesis and bone resorption in vitro and in vivo

Irisin, a skeletal-muscle secreted myokine, facilitates muscle-bone crosstalk and skeletal remodeling in part by its action on osteoblasts and osteocytes. In this study, we investigated whether irisin directly regulates osteoclasts. In vitro, irisin (2–10 ng/mL) increased osteoclast differentiation...

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Bibliographic Details
Main Authors: Eben G Estell, Phuong T Le, Yosta Vegting, Hyeonwoo Kim, Christiane Wrann, Mary L Bouxsein, Kenichi Nagano, Roland Baron, Bruce M Spiegelman, Clifford J Rosen
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-08-01
Series:eLife
Subjects:
irisin
osteoclast
bone
resorption
remodeling
myokine
Online Access:https://elifesciences.org/articles/58172

Internet

https://elifesciences.org/articles/58172

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