Local angiotensin II contributes to tumor resistance to checkpoint immunotherapy

Local angiotensin II contributes to tumor resistance to checkpoint immunotherapy

Abstract Background Current checkpoint immunotherapy has shown potential to control cancer by restoring or activating the immune system. Nevertheless, multiple mechanisms are involved in immunotherapy resistance which limits the clinical benefit of checkpoint inhibitors. An immunosuppressive microen...

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Bibliographic Details
Main Authors: Guozhu Xie, Tan Cheng, Jie Lin, Lanfang Zhang, Jieling Zheng, Ying Liu, Guobo Xie, Baiyao Wang, Yawei Yuan
Format: Article
Language:English
Published: BMJ Publishing Group 2018-09-01
Series:Journal for ImmunoTherapy of Cancer
Subjects:
Renin-angiotensin system
Angiotensin II
Checkpoint inhibitor
Immunotherapy
Resistance
Online Access:http://link.springer.com/article/10.1186/s40425-018-0401-3

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http://link.springer.com/article/10.1186/s40425-018-0401-3

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