Ubiquitin-mediated degradation of Aurora kinases

Ubiquitin-mediated degradation of Aurora kinases

The Aurora kinases are essential regulators of mitosis in eukaryotes. In somatic cell divisions of higher eukaryotes the paralogues Aurora kinase A (AurA) and Aurora kinase B (AurB) play non-overlapping roles that depend on their distinct spatiotemporal activities. These mitotic roles of Aurora kina...

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Bibliographic Details
Main Authors: Catherine eLindon, Rhys eGrant, Mingwei eMin
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-01-01
Series:Frontiers in Oncology
Subjects:
Mitosis
Aurora kinase
AURKA
AURKB
APC/C
ubiquitin-mediated proteolysis
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2015.00307/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fonc.2015.00307/full

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