Distinct promoter methylation patterns of LKB1 in the hamartomatous polyps of Peutz-Jeghers syndrome and its potential in gastrointestinal malignancy prediction

Distinct promoter methylation patterns of LKB1 in the hamartomatous polyps of Peutz-Jeghers syndrome and its potential in gastrointestinal malignancy prediction

Abstract Background Peutz-Jeghers Syndrome (PJS) is known as a rare inherited polyposis due to the malfunction of serine/threonine kinase gene LKB1. However, not all of PJS patients carry LKB1 germline mutation. Previous researches have observed the elevated DNA methylation level in PJS polyps. Neve...

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Bibliographic Details
Main Authors: Teng Li, Wensheng Lin, Yilei Zhao, Jianping Zhu, Tao Sun, Li Ren
Format: Article
Language:English
Published: BMC 2020-08-01
Series:Orphanet Journal of Rare Diseases
Subjects:
DNA methylation
Peutz-Jeghers syndrome
Liver kinase B1
Hamartomatous polyp
Colorectal Cancer
Prognosis
Online Access:http://link.springer.com/article/10.1186/s13023-020-01502-9

Internet

http://link.springer.com/article/10.1186/s13023-020-01502-9

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