An anti-perfringolysin O monoclonal antibody cross-reactive with streptolysin O protects against streptococcal toxic shock syndrome

An anti-perfringolysin O monoclonal antibody cross-reactive with streptolysin O protects against streptococcal toxic shock syndrome

Abstract Objective Streptococcus pyogenes (Group A Streptococcus; GAS) causes a variety of infections that include life-threatening, severe invasive GAS infections, such as streptococcal toxic shock syndrome (STSS), with > 30% mortality rate, despite effective antibiotics and treatment options. S...

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Bibliographic Details
Main Authors: Takayuki Matsumura, Ayae Nishiyama, Michio Aiko, Akira Ainai, Tadayoshi Ikebe, Joe Chiba, Manabu Ato, Yoshimasa Takahashi
Format: Article
Language:English
Published: BMC 2020-09-01
Series:BMC Research Notes
Subjects:
Streptococcal toxic shock syndrome
Cholesterol-dependent cytolysins
Streptolysin O
Perfringolysin O
Neutralizing monoclonal antibody
Online Access:http://link.springer.com/article/10.1186/s13104-020-05264-2

Internet

http://link.springer.com/article/10.1186/s13104-020-05264-2

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