RB Regulates DNA Double Strand Break Repair Pathway Choice by Mediating CtIP Dependent End Resection

RB Regulates DNA Double Strand Break Repair Pathway Choice by Mediating CtIP Dependent End Resection

Inactivation of the retinoblastoma tumor suppressor gene (<i>RB1</i>) leads to genome instability, and can be detected in retinoblastoma and other cancers. One damaging effect is causing DNA double strand breaks (DSB), which, however, can be repaired by homologous recombination (HR), cla...

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Bibliographic Details
Main Authors: Yuning Jiang, Jason C. Yam, Clement C. Tham, Chi Pui Pang, Wai Kit Chu
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:International Journal of Molecular Sciences
Subjects:
RB
CtIP
homologous recombination
classical non-homologous end joining, micro-homology mediated end joining
resection
Online Access:https://www.mdpi.com/1422-0067/21/23/9176

Internet

https://www.mdpi.com/1422-0067/21/23/9176

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