Retinoic acid-induced CYP51 nuclear translocation promotes meiosis prophase I process and is correlated to the expression of REC8 and STAG3 in mice

Retinoic acid-induced CYP51 nuclear translocation promotes meiosis prophase I process and is correlated to the expression of REC8 and STAG3 in mice

Lanosterol 14 α-demethylase (CYP51) plays a crucial role in cholesterol biosynthesis. In gamete development, CYP51 is involved in initiating meiosis resumption in oocytes through its product, meiosis activating sterol (MAS). In this study, CYP51 was observed to localize within the nucleus of germ ce...

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Bibliographic Details
Main Authors: Xinyi Mu, Jia Wen, Qian Chen, Zhengpin Wang, Yijing Wang, Meng Guo, Yi Yang, JinRui Xu, Zhiqing Wei, Guoliang Xia, Mengye Yang, Chao Wang
Format: Article
Language:English
Published: The Company of Biologists 2018-11-01
Series:Biology Open
Subjects:
CYP51
Oocytes
Meiosis
Chromosome synapsis
Primordial follicle formation
Online Access:http://bio.biologists.org/content/7/11/bio035626

Internet

http://bio.biologists.org/content/7/11/bio035626

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