Imatinib Ameliorated Retinal Neovascularization by Suppressing PDGFR-α and PDGFR-β

Imatinib Ameliorated Retinal Neovascularization by Suppressing PDGFR-α and PDGFR-β

Background/Aims: Platelet-derived growth factors (PDGFs) have emerged as pivotal in pathological angiogenesis, which is a hallmark of various tumors and retinal diseases. Here we evaluated the anti-angiogenic effect of imatinib, an inhibitor of PDGF receptors α and β (PDGFR-α and -β), in retinal neo...

Full description

Bibliographic Details
Main Authors: Lingli Zhou, Xiaowei Sun, Zijing Huang, Tian Zhou, Xiaowei Zhu, Yan Liu, Jing Wang, Bing Cheng, Mei Li, Chang He, Xialin Liu
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2018-07-01
Series:Cellular Physiology and Biochemistry
Subjects:
Retinal neovascularization
Imatinib
PDGFR-α
PDGFR-β
Online Access:https://www.karger.com/Article/FullText/491726

Internet

https://www.karger.com/Article/FullText/491726

Similar Items