Kynurenine Pathway Metabolites in Humans: Disease and Healthy States

Tryptophan is an essential amino acid that can be metabolised through different pathways, a major route being the kynurenine pathway. The first enzyme of the pathway, indoleamine-2,3-dioxygenase, is strongly stimulated by inflammatory molecules, particularly interferon gamma. Thus, the kynurenine pa...

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Bibliographic Details
Main Authors: Yiquan Chen, Gilles J. Guillemin
Format: Article
Language:English
Published: SAGE Publishing 2009-01-01
Series:International Journal of Tryptophan Research
Subjects:
Online Access:http://www.la-press.com/kynurenine-pathway-metabolites-in-humans-disease-and-healthy-stat-a1204