Indirect DNA readout by an H-NS related protein: structure of the DNA complex of the C-terminal domain of Ler.

Ler, a member of the H-NS protein family, is the master regulator of the LEE pathogenicity island in virulent Escherichia coli strains. Here, we determined the structure of a complex between the DNA-binding domain of Ler (CT-Ler) and a 15-mer DNA duplex. CT-Ler recognizes a preexisting structural pa...

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Bibliographic Details
Main Authors: Tiago N Cordeiro, Holger Schmidt, Cristina Madrid, Antonio Juárez, Pau Bernadó, Christian Griesinger, Jesús García, Miquel Pons
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-11-01
Series:PLoS Pathogens
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22114557/?tool=EBI