Sinensetin Reduces Osteoarthritis Pathology in the Tert-Butyl Hydroperoxide-Treated Chondrocytes and the Destabilization of the Medial Meniscus Model Mice via the AMPK/mTOR Signaling Pathway

Sinensetin Reduces Osteoarthritis Pathology in the Tert-Butyl Hydroperoxide-Treated Chondrocytes and the Destabilization of the Medial Meniscus Model Mice via the AMPK/mTOR Signaling Pathway

As a common degenerative disease, osteoarthritis (OA) usually causes disability in the elderly and socioeconomic burden. Previous studies have shown that proper autophagy has a protective effect on OA. Sinensetin (Sin) is a methylated flavonoid derived from citrus fruits. Studies have shown that Sin...

Full description

Bibliographic Details
Main Authors: Wenxian Zhou, Yifeng Shi, Hui Wang, Caiyu Yu, Huanqing Zhu, Aimin Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Pharmacology
Subjects:
osteoarthritis
autophagy
apoptosis
AMPK/mTOR signaling pathway
sinensetin
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.713491/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.713491/full

Similar Items