Antimicrobial Action and Reversal of Resistance in MRSA by Difluorobenzamide Derivatives Targeted at FtsZ

Antimicrobial Action and Reversal of Resistance in MRSA by Difluorobenzamide Derivatives Targeted at FtsZ

The bacterial cell division protein, FtsZ, has been identified as a target for antimicrobial development. Derivatives of 3-methoxybenzamide have shown promising activities as FtsZ inhibitors in Gram-positive bacteria. We sought to characterise the activity of five difluorobenzamide derivatives with...

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Bibliographic Details
Main Authors: Wern Chern Chai, Jonathan J Whittall, Di Song, Steven W Polyak, Abiodun D Ogunniyi, Yinhu Wang, Fangchao Bi, Shutao Ma, Susan J Semple, Henrietta Venter
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Antibiotics
Subjects:
antimicrobial resistance
antimicrobial development
reversing resistance
FtsZ inhibitors
3-methoxybenzamide
methicillin resistant Staphylococcus aureus
Online Access:https://www.mdpi.com/2079-6382/9/12/873

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https://www.mdpi.com/2079-6382/9/12/873

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