Methylprednisolone Pulses Plus Tacrolimus in Addition to Standard of Care vs. Standard of Care Alone in Patients With Severe COVID-19. A Randomized Controlled Trial

Methylprednisolone Pulses Plus Tacrolimus in Addition to Standard of Care vs. Standard of Care Alone in Patients With Severe COVID-19. A Randomized Controlled Trial

Introduction: Severe lung injury is triggered by both the SARS-CoV-2 infection and the subsequent host-immune response in some COVID-19 patients.Methods: We conducted a randomized, single-center, open-label, phase II trial with the aim to evaluate the efficacy and safety of methylprednisolone pulses...

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Main Authors: Xavier Solanich, Arnau Antolí, Gemma Rocamora-Blanch, Núria Padullés, Marta Fanlo-Maresma, Adriana Iriarte, Francesca Mitjavila, Olga Capdevila, Antoni Riera-Mestre, Jordi Bas, Vanesa Vicens-Zygmunt, Jordi Niubó, Nahum Calvo, Santiago Bolivar, Raúl Rigo-Bonnin, Anna Mensa-Vilaró, Laura Arregui, Cristian Tebe, Sebastià Videla, Pilar Hereu, Xavier Corbella
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Medicine
Subjects:
COVID-19
SARS-CoV-2
methylprednisolone
tacrolimus
inflammation
lung injury
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2021.691712/full

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https://www.frontiersin.org/articles/10.3389/fmed.2021.691712/full

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