HDAC4 Levels Control Sensibility toward Cisplatin in Gastric Cancer via the p53-p73/BIK Pathway

HDAC4 Levels Control Sensibility toward Cisplatin in Gastric Cancer via the p53-p73/BIK Pathway

Gastric cancer (GC) remains a health issue due to the low efficiency of therapies, such as cisplatin. This unsatisfactory situation highlights the necessity of finding factors impacting GC sensibility to therapies. We analyzed the cisplatin pangenomic response in cancer cells and found HDAC4 as a ma...

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Bibliographic Details
Main Authors: Marie-Elodie Spaety, Alexandre Gries, Amandine Badie, Aina Venkatasamy, Benoit Romain, Christophe Orvain, Kazuyoshi Yanagihara, Koji Okamoto, Alain C. Jung, Georg Mellitzer, Sébastien Pfeffer, Christian Gaiddon
Format: Article
Language:English
Published: MDPI AG 2019-11-01
Series:Cancers
Subjects:
mir-140
hdac4
p53
p73
bik
gastric cancer
cisplatin
Online Access:https://www.mdpi.com/2072-6694/11/11/1747

Internet

https://www.mdpi.com/2072-6694/11/11/1747

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