Sphingosine-1-phosphate inhibition of placental trophoblast differentiation through a Gi-coupled receptor response

Sphingosine-1-phosphate inhibition of placental trophoblast differentiation through a Gi-coupled receptor response

The failure of placental trophoblasts to differentiate properly is thought to play an important role in the cause of pregnancy disorders such as preeclampsia. We looked at the effects of the bioactive lipid sphingosine-1-phosphate (S1P) on the differentiation of primary human cytotrophoblasts (CTs)...

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Bibliographic Details
Main Authors: Edward D. Johnstone, Gary Chan, Colin P. Sibley, Sandra T. Davidge, Bonnie Lowen, Larry J. Guilbert
Format: Article
Language:English
Published: Elsevier 2005-09-01
Series:Journal of Lipid Research
Subjects:
sphingosine-1-phosphate receptors
adenosine 3′,5′-cyclic monophosphate
chorionic gonadotropin
fusion
epidermal growth factor
Gi proteins
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520329291

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http://www.sciencedirect.com/science/article/pii/S0022227520329291

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